Mity kontra fakty

Czyli medycyna prewencyjna w świetle najnowszych badań

lek. Katarzyna Świątkowska

wzmocnić odporność…źródła do artykułu

Share on facebook
Share on google
Share on twitter
Share on linkedin
  1. Hendley, J.O., and J.M. Gwaltney, Jr. 1988. Mechanisms of transmission of rhinovirus infections. Epidemiologic Reviews. 10:243-258
  2.  Gwaltney, J.M.Jr., and F.G. Hayden. 1992. Response to psychological stress and susceptibility to the common cold. New Engl. J. Med. 326:644-645.
  3. Jacobs SE, Lamson DM, St George K, Walsh TJ. Human rhinoviruses. Clin Microbiol Rev. 2013;26(1):135–162. doi:10.1128/CMR.00077-12
  4. Arroll B. Common cold. BMJ Clin Evid. 2011; 2011: 1510.
  5. Josling P. Preventing the common cold with a garlic supplement: A double-blind, placebo-controlled survey. Advances in Therapy. 2001;18(4):189–193.
  6. Simasek M., Blandino D. A. Treatment of the common cold. American Family Physician. 2007;75(4):515–522.
  7. Padayatty SJ, Levine M. Vitamin C: the known and the unknown and Goldilocks. Oral Dis. 2016;22(6):463–493. doi:10.1111/odi.12446
  8. Winther B, Gwaltney JM, Hendley JO. Respiratory virus infectionof monolayer cultures of human nasal epithelial cells. Am Rev Respir Dis 1990;141:839-45.
  9. The role of neutrophils in the pathogenesis of rhinovirus infections. Pediatr Infect Dis J 1990;9:832-5.
  10. Naclerio RM, Proud D, Lichtenstein LM, et al. Kinins are generated during experimental rhinovirus colds. J Infect Dis 1988;157:133-42.
  11. Liu R, Nikolajczyk BS. Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond. Front Immunol. 2019;10:1587. Published 2019 Jul 17. doi:10.3389/fimmu.2019.01587
  12. Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab. 2013;17(6):851–859. doi:10.1016/j.cmet.2013.05.008
  13. Inflammatory changes during the ‚common cold’ are associated with platelet activation and increased reactivity of platelets to agonists, Blood Coagul Fibrinolysis. 2007 Dec;18(8):713-8.
  14. Gwaltney, J.M.Jr., and R.R. Ruckert. 1997. Rhinovirus. In Clinical Virology. D.D. Richman, R.J. Whitley, and F.G. Hayden, editors. Churhill Livingstone, New York. 1025-1047.
  15. C.N. Camargo, E. Carraro, C.F. Granato, and N. Bellei, Human rhinovirus infections in symptomatic and asymptomatic subjects Braz J Microbiol. 2012 Oct-Dec; 43(4): 1641–1645.
  16.  Asymptomatic rhinovirus infection outnumbers symptomatic infection 4 to 1 among university students, Andrea Granados, Emma Goodall, Marek Smieja, James Mahony, 2012 American Society for Microbiology General Meeting, McFlu2 COLD3 clinical trial
  17. Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence. Food Nutr Bull. 2009;30:S41–59.
  18. Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008;14(5-6):353–357. doi:10.2119/2008-00033.Prasad
  19. Wong, C. P., Rinaldi, N. A. and Ho, E. (2015), Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol. Nutr. Food Res., 59: 991-999.
  20. Buczek S., Jabłoński E. Składniki mineralne i witaminy w diecie redukcyjnej dzieci otyłych. Pediatr. Współcz. 2004,6/2,121–125
  21.  Koźlicka I., Przysławski J.: Wpływ cynku na występowanie i przebieg procesów chorobowych u dzieci. Bromat. Chem. Toksykol. 2007, 1: 57–62.
  22.  Uzdymowicz-Farbiszewska J., Smorczewska-Czupryńska B., Karczewski J., Fiłoń J.: Ocena zawartości cynku żelaza w całodziennych racjach pokarmowych studentów studiów niestacjonarnych AMP. Bromat. Chem. Toksykol. 2008, 1: 35–40.
  23. Farrell CP, Morgan M, Rudolph DS, et al. Proton Pump Inhibitors Interfere With Zinc Absorption and Zinc Body Stores. Gastroenterology Res. 2011;4(6):243–251.
  24. Cabrera A.J.R. Zinc, aging, and immunosenescence: an overview. Pathobiol. Aging Age Relat. Dis. 2015; 5: 25592, doi: 10.3402/pba.v5.25592.
  25. Oberleas D., Harland B.F. Treatment of zinc deficiency without zinc fortification. J. Zhejiang Univ. Sci. B 2008; 9(3): 192–196.
  26. Rao G, Rowland K. PURLs: Zinc for the common cold–not if, but when. J Fam Pract. 2011;60(11):669–671.
  27. Singh M, Das RR Zinc for the common cold. Cochrane Database Syst Rev. 2013 Jun 18; (6):CD001364.
  28. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984;25:20–24..
  29. Jackson JL, Lesho E, Peterson C. Zinc and the common cold: a meta-analysis revisited. J Nutr. 2000;130 (5 suppl):1512S–1515S
  30. Hemila H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J. 2011;5:51–58..
  31. A. Duncan, C. Yacoubian, N. Watson, I. Morrison. The risk of copper deficiency in patients prescribed zinc supplements. Journal of Clinical Pathology, 2015; DOI: 10.1136/jclinpath-2014-202837
  32. Hemilä H, Haukka J, Alho M, et alZinc acetate lozenges for the treatment of the common cold: a randomised controlled trialBMJ Open 2020;10:e031662. doi: 10.1136/bmjopen-2019-031662
  33. Galan P,  Viteri FE,  Bertrais S, et al. Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population, Eur J Clin Nutr, 2005, vol. 59 10(pg. 1181-1190)
  34. Löwik MR,  Hulshof KF,  Schneijder P, et al. Vitamin C status in elderly women: a comparison between women living in a nursing home and women living independently, J Am Diet Assoc., 1993, vol. 93 2(pg. 167-172)
  35. Johnston CS,  Corte C,  Swan PD. Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults [electronic article], Nutr Metab (Lond), 2006, vol. 3 pg. 35
  36. Hampl JS,  Taylor CA,  Johnston CS. Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994, Am J Public Health, 2004, vol. 94 5(pg. 870-875)
  37. Leah Cahill, Paul N. Corey, Ahmed El-Sohemy, Vitamin C Deficiency in a Population of Young Canadian Adults, American Journal of Epidemiology, Volume 170, Issue 4, 15 August 2009, Pages 464–471,
  38. Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;1:CD000980
  39. Pitt H. A., Costrini A. M. Vitamin C Prophylaxis in Marine Recruits. Journal of the American Medical Association. 1979;241(9):908–911. doi: 10.1001/jama.1979.03290350028016.
  40. Constantini N. W., Dubnov-Raz G., Eyal B.-B., Berry E. M., Cohen A. H., Hemilä H. The effect of vitamin C on upper respiratory infections in adolescent swimmers: A randomized trial. European Journal of Pediatrics. 2011;170(1):59–63.
  41.  Hemilä H., Chalker E. Vitamin C for Preventing and Treating the Common Cold. The Cochrane Library; 2013. CD000980
  42. Hemilä H. Do Vitamins C and E Affect Respiratory Infections? Helsinki, Finland: University of Helsinki; 2006.
  43. Ran L, Zhao W, Wang J, et al. Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials. Biomed Res Int. 2018;2018:1837634. Published 2018 Jul 5. doi:10.1155/2018/1837634
  44. Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2007;(3):CD000980. Published 2007 Jul 18. doi:10.1002/14651858.CD000980.pub3
  45. Shilotri PG, Bhat KS., Effect of mega doses of vitamin C on bactericidal ativity of leukocytes., Am J Clin Nutr. 1977 Jul;30(7):1077-81.
  46. Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. Critical Review. J Nutr 2007;137:2171-84.
  47. Naidu AK. Vitamin C in human health and disease is still a mystery ? An overview. Nutr J 2003;2:1-10
  48. Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care 2002;5:66-74.
  49. Nasr, S.H. et al. Secondary oxalosis due to excess vitamin C intake, Kidney International, Volume 70, Issue 10, 1672
  50. Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23.
  51. Lee DH, Folsom AR, Harnack L, Halliwell B, Jacobs DR Jr. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200.
  52. Adit A. Ginde MD, MPH Patrick Blatchford PhD Keith Breese MA Lida Zarrabi MPH Sunny A. Linnebur PharmD Jeffrey I. Wallace MD, MPH Robert S. Schwartz , High‐Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long‐Term Care Residents: A Randomized Clinical Trial
  53. Ambrosioni J, Bridevaux PO, Wagner G, Mamin A, Kaiser L. Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011-2012. Clin Microbiol Infect. 2014;20:O578–O584. [PubMed]
  54. Holick MF. Photobiology of vitamin D. In: Feldman D, Pike JW, Adams JS, editors. London: Academic Press; 2011. pp. 13–22. Vitamin D. Vol. 1.
  55. Camargo CA, Jr, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, Town GI, Pattemore PK, Espinola JA, Crane J New Zealand Asthma and Allergy Cohort Study Group. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127:e180–e187.
  56. Quraishi SA, Bittner EA, Christopher KB, Camargo CA., Jr Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PLoS One. 2013;8:e81120
  57. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 May; 91(5):1255-60.
  58. Camargo CA, Jr, Ganmaa D, Frazier AL, Kirchberg FF, Stuart JJ, Kleinman K, Sumberzul N, Rich-Edwards JW. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics. 2012;130:e561–e567
  59. Laaksi I., Ruohola J.-P., Mattila V., Auvinen A., Ylikomi T., Pihlajamäki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: A randomized, double-blinded trial among young finnish men. 2010;202(5):809–814.
  60. Charan J., Goyal J. P., Saxena D., Yadav P. Vitamin D for prevention of respiratory tract infections: a systematic review and meta-analysis. 2012;3(4):300–303. doi: 10.4103/0976-500x.103685.
  61. Hansen KE, Johnson MG. An update on vitamin D for clinicians. Curr Opin Endocrinol Diabetes Obes. 2016;23(6):440–444. doi:10.1097/MED.0000000000000288
  62. Denlinger LC, King TS, Cardet JC, et al. Vitamin d supplementation and the risk of colds in patients with asthma. Am J Respir Crit Care Med. 2016;193:634–641.
  63. Martineau AR, Hanifa Y, Witt KD, et al. Double-blind randomised controlled trial of vitamin d3 supplementation for the prevention of acute respiratory infection in older adults and their carers (vidiflu) Thorax. 2015;70:953–960
  64. Martineau, A.R. (2015), ‘Curiouser and curiouser’: the role of vitamin D in the prevention of acute respiratory infection. Acta Paediatr, 104: 331-333.
  65. Winther B, McCue K, Ashe K, Rubino J, Hendley JO., Rhinovirus contamination of surfaces in homes of adults with natural colds: transfer of virus to fingertips during normal daily activities. J Med Virol. 2011 May;83(5):906-9.
  66. Ejemot RI, Ehiri JE, Meremikwu MM, Critchley JA. Hand washing for preventing diarrhoea.external icon Cochrane Database Syst Rev. 2008;1:CD004265.
  67. Aiello AE, Coulborn RM, Perez V, Larson EL. Effect of hand hygiene on infectious disease risk in the community setting: a meta-analysis.external icon Am J Public Health. 2008;98(8):1372-81.
  68. Huang DB, Zhou J. Effect of intensive handwashing in the prevention of diarrhoeal illness among patients with AIDS: a randomized controlled study.external icon J Med Microbiol. 2007;56(5):659-63.
  69. Rabie T and Curtis V. Handwashing and risk of respiratory infections: a quantitative systematic review.external icon Trop Med Int Health. 2006 Mar;11(3):258-67.
  70. Burton M, Cobb E, Donachie P, Judah G, Curtis V, Schmidt WP. The effect of handwashing with water or soap on bacterial contamination of hands.external icon Int J Environ Res Public Health. 2011 Jan;8(1):97-104.
  71. Azor-Martínez E, Cobos-Carrascosa E, Gimenez-Sanchez F, Martínez-López JM, Garrido-Fernández P, Santisteban-Martínez J, Seijas-Vazquez ML, Campos-Fernandez MA, Bonillo-Perales A. Effectiveness of a multifactorial handwashing program to reduce school absenteeism due to acute gastroenteritis.external icon Pediatr Infect Dis J. 2013 Oct 3.
  72. Lau CH, Springston EE, Sohn MW, Mason I, Gadola E, Damitz M, Gupta RS. Hand hygiene instruction decreases illness-related absenteeism in elementary schools: a prospective cohort study.external icon BMC Pediatr. 2012;12:52.
  73. Master D, Hess Longe SH, Dickson H. Scheduled hand washing in an elementary school population.external icon Fam Med. 1997;29(5):336-9.
  74. Ryan MA, Christian RS, Wohlrabe J., Am J Prev Med. 2001 Aug;21(2):79-83. Handwashing and respiratory illness among young adults in military training.
  75. Ejemot RI, Ehiri JE, Meremikwu MM, Critchley JA. Hand washing for preventing diarrhoea. Cochrane Database Syst Rev. 2008;1:CD004265.
  76. Aiello AE, Coulborn RM, Perez V, Larson EL. Effect of hand hygiene on infectious disease risk in the community setting: a meta-analysis. Am J Public Health. 2008;98(8):1372-81.
  77. Aiello AE, Coulborn RM, Perez V, Larson EL. Effect of hand hygiene on infectious disease risk in the community setting: a meta-analysis. Am J Public Health. 2008;98(8):1372-81.
  78. Rabie T and Curtis V. Handwashing and risk of respiratory infections: a quantitative systematic review.Trop Med Int Health. 2006 Mar;11(3):258-67.
  79. Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med. 1991;325(9):606–612. doi:10.1056/NEJM199108293250903
  80. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012;109(16):5995–5999.
  81. Nieman DC, Henson DA, Austin MD, Brown VA. Immune response to a 30-minute walk. Med Sci Sports Exerc. 2005;37(1):57–62. doi:10.1249/01.mss.0000149808.38194.21
  82. Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987–992. doi:10.1136/bjsm.2010.077875
  83. Nieman DC, Henson DA, Austin MD, Brown VA. Immune response to a 30-minute walk. Medicine and Science in Sports and Exercise. 2005 Jan;37(1):57-62. DOI: 10.1249/01.mss.0000149808.38194.21.
  84. Lee HK, Hwang IH, Kim SY, Pyo SY. The effect of exercise on prevention of the common cold: a meta-analysis of randomized controlled trial studies. Korean J Fam Med. 2014;35(3):119–126. doi:10.4082/kjfm.2014.35.3.119
  85. Irwin M, Mascovich A, Gillin JC, Willoughby R, Pike J, Smith TL. Partial sleep deprivation reduces natural killer cell activity in humans. Psychosom Med. 1994;56(6):493–498. doi:10.1097/00006842-199411000-00004
  86. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL, An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005 Jul 15; 122(1):107-18.
  87. Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, Grigg ME, Berzofsky JA, Belkaid Y Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity. 2008 Oct 17; 29(4):637-49.
  88. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.Nat Immunol. 2008 Jul; 9(7):769-76
  89. Doyle S, Vaidya S, O’Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng GIRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 2002 Sep; 17(3):251-63.
  90. Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.Science. 2009 Oct 9; 326(5950):257-63.
  91. Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A, Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5354-9.
  92.  Fitzgerald K, NLR-containing inflammasomes: central mediators of host defense and inflammation. Eur J Immunol. 2010 Mar; 40(3):595-8.
  93.  Allen IC, et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity. 2009;30:556–565.
  94. Thomas PG, et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity. 2009;30:566–575.
  95.  Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med. 2009;16:79–87
  96. Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, Larosa DF, Renner ED, Orange JS, Bushman FD, Artis D, Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.Nat Med. 2012 Mar 25; 18(4):538-46.
  97. Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med. 2010 Feb;16(2):228-31. doi: 10.1038/nm.2087. Epub 2010 Jan 17
  98. Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012 Jul 27; 37(1):158-70.
  99. Kunachowicz H., Przygoda B., Nadolna I., Iwanow K., 2017, Tabele składu i wartości odżywczej żywności, Wydawnictwo Naukowe PWN, Warszawa.
  100.  
Katarzyna

Katarzyna

Zostaw komentarz

Katarzyna Świątkowska

lekarz medycyny

Jestem absolwentką Akademii Medycznej w Gdańsku, mieszkam i prowadzę praktykę lekarską w pięknym mieście na Pomorzu Zachodnim.
Od lat staram się przekonywać swoich pacjentów i czytelników mojej strony, że dbałość o zdrowie nie polega na gonitwie za modnymi suplementami i magicznej wierze, że lekarz załatwi za nas wszystko.
Zależy mi niezwykle, by najnowsze doniesienia naukowe dotarły do jak najszerszego kręgu odbiorców. Przyznaję, że traktuję to jako moją misję życiową.